Join us!

We are looking for new colleagues who are passionate about the biology of chromatin and the nucleus. The goals of the Laboratory of Genome Architecture and Dynamics is to apply an interdisciplinary, quantitative approach that draws on methods from genomics, biophysics, cell biology, and modeling to understand structure-function relationships in chromatin organization. We are building a mutually supportive community of diverse scientists who will help each other learn new approaches and do their best work. If this sounds good to you, please join us!

Postdoctoral Scholars

Multiple postdoctoral scholar positions are available on projects including development of next-generation methods for in situ chromatin structure mapping, modeling chromatin fiber conformations at the oligo-nucleosome scale, exploring the biophysical mechanisms involved in transcriptional repression in mammalian cells, and studying how DNA replication and exit from the cell cycle affect chromatin structure. (Please see the Research page for more details.)

Postdocs in the Risca Lab will help build a lab at the intersection of cutting-edge epigenomics and biophysics and will have extensive opportunities for skill building, collaboration, mentoring, and development of an independent research program. Applications from highly motivated, talented and collegial candidates with a Ph.D. in a relevant area (including molecular or cell biology, biophysics, biochemistry, chemistry, physics, applied mathematics, bioengineering) are encouraged.

To apply: Please submit a CV, PDFs of any unpublished manuscripts that are not otherwise available, and contact information for at least three references, by email to Please use “Postdoc application” as the subject line. After an initial video or phone interview, you will be asked to have three of your references submit letters of recommendation.

Graduate Students

Students from all backgrounds are welcome in the Risca Lab and will have the opportunity to pursue fundamental questions in chromatin biology, develop novel technologies that probe genome architecture at high resolution, and apply the lab’s epigenomics toolkit to understanding chromatin-based mechanisms that drive disease processes including malignant transformation and drug resistance (see Research). We are looking for passionate, enthusiastic students who want to help build a lab based on excellence and mutual support and are eager to learn in an interdisciplinary environment. Please apply to the David Rockefeller Graduate Program in Bioscience or the Tri-Institutional MD-PhD Program.