https://riscalab.org/overview daily 1.0 2021-07-19 https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626472212692-EQQ60XKLYB8WCKV6MPV2/chromatinstucture1_extrabright.jpg Overview - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1538011775533-IPAYZ10JQQS00K7BVKBW/Fig1_Chromatin_Architecture_Scales_Website_V1_White.jpg Overview https://riscalab.org/research daily 0.75 2021-10-31 https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626468577422-R8J481TH089YJNG89QAV/Screen+Shot+2021-07-16+at+4.49.26+PM.png Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1613759059883-TRE65YTZKC6FJGOFWLKH/Fig1_Chromatin_Architecture_Scales_Website_Transparent.png Research Adapted from Risca & Greenleaf, Trends in Genetics, 2015 https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1538982022467-9OSBUGOXYDWFE9ZT1HPD/CorrelatedCleavageConcept-01.png Research Risca et al., Nature, 2018 https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1538985882836-EM68SG0PXTUFYZKB24XU/RICCTracks.png Research Risca et al., Nature, 2018 https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1538986549919-Y3R801U4XILNA4XFHVVY/Image021_ch00_Crop.jpg Research https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1538985803650-VQTXN7YG5Y5S1Z59I8F8/ChAR-seq.png Research Bell et al., eLife, 2018 https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1538988222808-KXT41J9D86ULYPZVCE93/IMG_2147.jpg Research https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1604292852382-NOQMOWKQIWXHLVUEXJHO/28DaySenescentLS8817-ATRX.jpg Research Liposarcoma cells stained with an antibody agains ATRX, a chromatin component that forms foci during senescence. https://riscalab.org/publications daily 0.75 2023-03-31 https://riscalab.org/people daily 0.75 2023-03-31 https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626471901586-MBD5UMEC5D0UCRH5PH2O/PC%3A+Jonathan+Pritchard People - Viviana I. Risca vrisca@rockefeller.edu Assistant Professor, The Rockefeller University Ph.D. Biophysics, University of California, Berkeley, 2012 Postdoc, Depts. of Genetics & Biochemistry, Stanford University CV Contact Us Office: Flexner FA06 Phone: 212-327-7099 https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626467095466-K97F357MCQWHIMG7EQC3/JanHeadshot.jpg People - Jan Soroczynski jsoroczyns@rockefeller.edu Graduate Fellow, David Rockefeller Graduate Program Boehringer Ingelheim Fonds PhD Fellow MBiochem, Molecular and Cellular Biochemistry, University of Oxford, 2016 Jan is interested in understanding how SMC complexes navigate and perturb local chromatin structure to dynamically shape genomes. https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626467065811-RIRSQI51R0IEV4E95CMJ/AndrewHeadshot.jpg People - Andrew Scortea ascortea@rockefeller.edu Research Specialist, The Rockefeller University M.S. Biochemistry and Cell Biology, Stony Brook University, 2016 Andrew is the lab manager for the Risca Lab. His previous lab focused on Mitochondrial biology and pathology, aging, and metabolism. He is excited to begin anew in the exciting field of chromatin structure and biology! Desk: Flexner FA26 Phone: 212-327-7304 https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626467325759-YSY8WWFF6M2Z0LQOST58/JustinHeadshot.jpg People - Justin Rendleman jrendleman@rockefeller.edu Postdoctoral Associate, Rockefeller University Ph.D. Biology, NYU, 2021 Justin is interested in the molecular basis underlying cell-state transitions, and particularly the regulation that drives decisions made by cancer cells. He’s studying how dynamic changes in the chromatin landscape impact cells forced to exit the cell cycle and the choice between entering a state of quiescence or senescence. https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1629828105614-UH961JLTFS7UX9GW7GVP/MicrosoftTeams-image+%281%29.jpeg People - Hera Canaj hcanaj@rockefeller.edu Graduate Fellow, David Rockefeller Graduate Program B.S. Genetics, Western University, 2017 Hera is keen to investigate how the linker histone is implicated in regulating higher order nuclear organization. She's also interested in probing the role of noncoding RNAs in maintaining, or disrupting genome organization. https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/14b4a9c7-c4e5-44eb-9514-d9ff4a0eed59/MicrosoftTeams-image+%285%29.jpg People - Lauren Anderson landerson01@rockefeller.edu B.S. Biology, George Washington University, 2019 Lauren is interested in chromatin-mediated transcriptional repression and linker histones role in chromatin structure. https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1570130122498-GG2G9E901Y5IBAUEX0FP/DSC_0049.jpg People - Nicole Pagane Research Assistant, The Rockefeller University B.A. Biophysics, Johns Hopkins University, 2019 Current position: Graduate student, MIT Computational Systems Biology https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626467027902-0UJP5R1N0BUTJHGG7FWF/ArnoldHeadshot.jpg People - Arnold Ou aou@rockefeller.edu Postdoctoral Associate, The Rockefeller University Ph.D. Chemistry, University of Western Australia, 2020 Arnold is developing orthogonal probing techniques to RICC-seq, such as chemical cleavage, to more deeply cover selected regions of the genome. He is also helping to establish our in vitro chromatin reconstitution capabilities. https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626467121282-FGLRT2MP0EXAHCC6KT3J/DevanyHeadshot.jpg People - Devany West dwest@rockefeller.edu Graduate Fellow, David Rockefeller Graduate Program B.S. Biological Engineering, MIT, 2018 Devany is interested in using data fitting methods to connect structures from computational modeling to experimental results from RICC-seq, ATAC-seq, Micro-C and other genomic methods. https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1623961792112-FE590LYK112WTDQE1HYN/IMG_8033.jpg People - Jerome Jerome is a snake. https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626466970497-W99CJE42Y4XTL3JLKE62/AndresHeadshot.jpg People - Andrés Mansisidor mansisidor@rockefeller.edu Postdoctoral Associate, The Rockefeller University Ph.D. Biology, New York University, 2019 Andrés hearts all things DNA, but they are especially interested in understanding how chromatin organization influences the transcription and replication of episomal DNAs, including oncogenic extrachromosomal DNA circles and circular DNA viruses. Andrés is also keen on mentoring and science outreach through RockEdu. https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626466937765-73N5ZHT04V1SS8ELE4UP/IreneHeadshot.jpg People - Irene Duba iduba@rockefeller.edu Graduate Fellow, David Rockefeller Graduate Program B.A. Physics, Lewis & Clark College, 2017 Irene is the resident linker histone fan of the lab. She's interested in exploring how linker histone affects chromatin compaction, using RICC-seq and other genomic techniques. Irene is also the Risca lab tea master. https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626466898983-DSVKNNHZBW1AIROEDQ5R/ArianaHeadshot.jpg People - Ariana Clerkin abrenner@rockefeller.edu Graduate Student, Tri-Institutional Computational Biology and Medicine Ph.D. Program B.A. Biochemistry, University of Pennsylvania, 2016 M.S. Chemistry, University of Pennsylvania, 2016 Ariana is interested in developing a computational pipeline to identify heterochromatin folding patterns in repetitive regions of the genome. She is also interested in modeling chromatin dynamics. https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626467156142-QG6RLAJ2R4DE4VURHJFW/JoannaHeadshot.jpg People - Joanna Yeung jyeung@rockefeller.edu Graduate Fellow, David Rockefeller Graduate Program B.S. Pharmacology & Toxicology, University of Toronto, 2019 Joanna is studying dynamics of the chromatin landscape through senescence. She enjoys learning the ins and outs of bioinformatics. Outside of the lab, Joanna has several hobbies, including but not limited to running, taking naps, watching anime, listening to kpop, karaoke and bribing Risca lab members with cookies. https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626472072369-IDPG8KPH22A00LI9AC16/Screen+Shot+2021-07-16+at+4.40.01+PM.png People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://riscalab.org/contact daily 0.75 2021-02-19 https://riscalab.org/fun daily 0.75 2021-07-16 https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626469091577-URPL4GTKFA0S9GLRUQFW/FullLabNucleosomes.jpg Fun - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1570128100991-YRW7KJ1AFQHACJMZFVEC/Attachment-1.jpeg Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1565873449672-4MG0VBYWVBI62K5GHAE7/2019-08-06-WeEscapedTheRoomIn1963.jpg Fun - We escaped the escape room! Summer 2019 (circa Clue Chase, 1963) https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1565873416752-Q9823MUJZNAIVPH4X5QH/2018-12-20-HelloRockefeller.jpg Fun - Hello, Collaborative Research Center at RU Winter 2018 https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1565873424631-AHHHUT4ISG1GP3J78LOO/2019-04-19-FirstIlluminaAndIDTOrder.jpg Fun - First Illumina and IDT order Spring 2019 https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1565873435413-RDVF8IOW332LXVKVOEZW/2019-07-12-FirstMiSeqRun.jpg Fun - First MiSeq run on RICC-seq data! Summer 2019 https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1565873438671-AS1RU5HHUR45CI1BDE63/2019-08-02-TheRUGoodfeathers.jpg Fun - The RU Good Feathers Summer 2019 https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1565873431217-CJZ67FHFVAI0GB46IUDD/2019-06-20-LabLunch01.jpg Fun - Lab lunch at Up Thai Summer 2019 https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1570128547054-7POHS8ARK67U1XP8WD59/IMG_2682.JPG Fun - Prairie Dogs Fall 2019 https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1565873456497-6BJ9AGWW5LXFIEQDF407/2019-08-08-RUDucklings.jpg Fun - RU Ducklings :) Summer 2019 https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1613755581656-QQMZGA4955I40BQPLW6L/Arnold_Birthday_eclairs_11-20-2020.jpg Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1613755581687-OUFVHS3N9LWY6VTZRGEI/3AM_ATACseq_1-23-2021.jpg Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1613755582054-DYIY5G8L3ZOZZQA1QEGY/SRSLY_1-4-2021.jpg Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1613755582316-LGASPOONB6Y5AF66G7O8/Irene_dressed_like_the_Joker_12-2020.jpg Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1613755582838-XJZ025Y1CJR7CMOON6HF/20201210_Nicole_s_talk.jpg Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1613755583056-4WNF1ESORE0XUWJ81G79/20201217_RiscaLabsnowman_in_collaboration_with_camila_fromtheHudspethlab.jpg Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1613755583300-24RM2LH62FORDP0W5DN1/Arnold_homemade_cake_wascalledsomethingfancylikedaquoisithink_Nov2020.jpg Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1613755583609-PU7GC44H0FYRKKLV2OCA/20201217_Riscalab_snowman_with_arnold.jpg Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1613755583784-2K9FC8QH3144SOMIT4I9/Irenebeingeffortless_Nov2020.jpg Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1613755583966-OGIP3SJ3U1WHTVTIZMIN/Nov2020-Hera.jpg Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1613755584240-Z1Y07QTKPJG5WC1QIVBX/Reunion+with+Nicole+Jan+2021.jpg Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626470304157-S1AUPTVFQ69EOWMJQPB8/Screen+Shot+2021-07-16+at+5.18.14+PM.png Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626470390860-01JH8FQT8PZPFUF2UZIR/Screen+Shot+2021-07-16+at+5.19.19+PM.png Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626470620714-L12C2RUYPLQEE64IZVBO/IMG_7374.png Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626470632616-ETLR5E2SGVSQPLM1R910/IMG_3741+2.png Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626470691063-5NNH96LAPKPQX4RJJ1GX/IMG_3747+2.png Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626470717573-81IQ3008L889DD5MOL9J/IMG_3745+2.png Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626470755427-J6RLQ4A4EXTLPADIEVRA/IMG_3742+2.png Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626470817199-FLPEGQCALR0VOYCTNG4B/IMG_3743+2.png Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626470843857-0OIEM13C16HGZD9BBZDC/FullLabJauntyAngle.jpg Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626470850447-P8V3DR1H8DTQZR93LMVR/FullLabHearts.jpg Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626472951570-V95D1CDHN4C36OSE9UAU/MicrosoftTeams-image.png Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626472968404-JBX9BYICJQK8KCSHM3UG/MicrosoftTeams-image%281%29.png Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1626472982633-CBRXICS41S0QMN7X92SX/MicrosoftTeams-image%282%29.png Fun https://images.squarespace-cdn.com/content/v1/5b429525b98a78d677faf718/1588878160475-CCTFDCS9ZUG5NUETLED4/RiscaLabZoomGroupPhoto2.png Fun